Glepaglutide/914009-86-2/Glepaglutide Peptide

PeptideName：Glepaglutide/914009-86-2/Glepaglutide Peptide

Catalog No：GT-L005

Sequence：HGEGTFSSELATILDALAARDFIAWLIATKITDKKKKKK-NH2

CAS Number：914009-86-2

Molecular Formula：C197H325N53O55

Molecular Weight：4316.01

Category：Glepaglutide,914009-86-2,Peptide synthesis,Peptide raw material company

Description：Glepaglutide (ZP1848, CAS 914009-86-2) is a long-acting GLP-2 analog developed by Zealand Pharma. Through nine amino acid substitutions and C-terminal hexalysine modification (SIP technology), it acquires DPP-IV resistance, good water solubility and prolonged pharmacokinetics, achieving long-acting effects via a depot effect without requiring albumin binding.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

Which end is best for my research?

By default, the peptide ends with an N-terminal free amino group and a C-terminal free carboxyl group. The peptide sequence often represents the sequence of the mother protein. In order to be closer to the mother protein, the end of the peptide often needs to be closed, that is, n-terminal acetylation and C-terminal amidation. This modification avoids the introduction of excess charge, and also makes it more able to prevent exonucliase action, so that the peptide is more stable.

Is it necessary to put a gap between the peptide and the dye?

If you are going to attach a large molecule (such as a dye) to the peptide, it is best to put a space between the peptide and the ligand to minimize interference with the receptor by the folding of the peptide itself or by the folding of its conjugate. Others do not want intervals. For example, in the folding of proteins, it is possible to determine how far apart the folding structure of an amino acid is by attaching a fluorescent dye to a particular site.

If a Glepaglutide is 98% pure, what is 2%?

Two percent of the composition was truncated or deleted sequence fragments.

Were the peptides containing Cys reduced before shipment?

If the peptide is not found to have been oxidized, we generally do not reduce Cys. All polypeptides are obtained from crude products purified and lyophilized under pH2 conditions, which at least to some extent prevent the oxidation of Cys. Peptides containing Cys are purified at pH2 unless there is a specific reason to purify at pH6.8. If purification is performed at pH6.8, the purified product must be treated with acid immediately to prevent oxidation. In the final quality control step, for the peptides containing Cys, if the presence of molecular weight (2P+H) substance is found on the MS map, it indicates that a dimer has been formed. If there is no problem with MS and HPLC, we will directly lyophilize and ship the goods without any further processing. It should be noted that peptides containing Cys undergo slow oxidation over time, and the degree of oxidation depends on peptide sequence and storage conditions.