INF7,185462-59-3,Peptide synthesis,Peptide raw material company
- Product Description
PeptideName：INF7/185462-59-3/Peptide synthesis
Catalog No：GT-M24118
Sequence：H-Gly-Leu-Phe-Glu-Ala-Ile-Glu-Gly-Phe-Ile-Glu-Asn-Gly-Trp-Glu-Gly-Met-Ile-Asp-Gly-Trp-Tyr-Gly-Cys-OH
CAS Number：185462-59-3
Molecular Formula：C124H169N27O37S2
Molecular Weight：2693.95
Category：INF7,185462-59-3,Peptide synthesis,Peptide raw material company
Description：INF7 has wide applications in the fields of biological delivery systems and research tools. It can significantly enhance the intracellular delivery efficiency of substances such as proteins, nucleic acids, and molecular imaging probes encapsulated in complexes or liposomes. For example, when co-encapsulated with molecular imaging probes in liposomes, it can increase intracellular signal intensity and probe retention time, extending the imaging window. Modification on the surface of gene delivery vectors can increase gene expression efficiency by 4 times. In the field of tumor therapy, INF7-modified nanodelivery systems can actively target tumor vascular endothelial cells, achieving precise delivery of chemotherapy drugs and reversing tumor multidrug resistance with low toxicity.
Specifications
Apperance: White to off-white powder
Purity(HPLC): ≥98.0%
Single Impurity: ≤2.0%
Acetate Content(HPLC): 5.0%～12.0%
Water Content (Karl Fischer): ≤10.0%
Peptide Content: ≥80.0%
Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.
FAQ：
Which end is best for my research?
By default, the peptide ends with an N-terminal free amino group and a C-terminal free carboxyl group. The peptide sequence often represents the sequence of the mother protein. In order to be closer to the mother protein, the end of the peptide often needs to be closed, that is, n-terminal acetylation and C-terminal amidation. This modification avoids the introduction of excess charge, and also makes it more able to prevent exonucliase action, so that the peptide is more stable.
What problems should be paid attention to in the storage process?
The peptide you received was packaged in lyophilized powder. Peptides are hydrophilic, and absorption of water will reduce the stability of the peptide and reduce the peptide content. Please pay attention to the following: first, with desiccants, stored in a dry environment. Second, once received, please immediately put into the freezer -20℃ storage, in order to maintain maximum stability. Third, avoid the use of no automatic frost function of the freezer. Changes in humidity and temperature can affect the stability of peptides. Fourth, the external temperature during transportation does not affect the validity and quality of peptides.
How do you dissolve polypeptides?
The solubility of polypeptide depends mainly on its primary and secondary structure, the nature of modification label, solvent type and final concentration. If the peptide is insoluble in water, ultrasound can help dissolve it. For basic peptide, it is recommended to dissolve with 10% acetic acid; For acidic peptides, dissolution with 10%NH4HCO3 is recommended. Organic solvents can also be added to insoluble polypeptides. The peptide is dissolved in the least amount of organic solvent (e.g., DMSO, DMF, isopropyl alcohol, methanol, etc.). It is highly recommended that the peptide be dissolved in the organic solvent first and then slowly added to water or other buffer until the desired concentration.
If a INF7 is 98% pure, what is 2%?
Two percent of the composition was truncated or deleted sequence fragments.
Is it necessary to put a gap between the peptide and the dye?
If you are going to attach a large molecule (such as a dye) to the peptide, it is best to put a space between the peptide and the ligand to minimize interference with the receptor by the folding of the peptide itself or by the folding of its conjugate. Others do not want intervals. For example, in the folding of proteins, it is possible to determine how far apart the folding structure of an amino acid is by attaching a fluorescent dye to a particular site.
