PT-141/189691-06-3/pt-141 peptide/pt-141 dosage

PeptideName：PT-141/189691-06-3/pt-141 peptide/pt-141 dosage

Catalog  No：GT-A005

Sequence：Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH  Chemical Bridge Asp2-Lys7

CAS Number：189691-06-3

Molecular Formula：C50H68N14O10

Molecular Weight：1025.16

Category：PT-141,189691-06-3,Peptide synthesis,Peptide raw material company

Description：The mechanism of action of PT-141 involves the non-selective activation of melanocortin receptor subtypes including MC1R, MC3R, and MC4R, among which binding to MC4R constitutes the core pathway. This receptor is highly expressed in central regions that regulate sexual behavior, such as the hypothalamus.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

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FAQ：

Why the n-terminal acetylation and C-terminal amidation?

These modifications prevent the peptide from being degraded and allow the peptide to mimic its original state of alpha amino and carboxyl groups in the parent protein.

What problems should be paid attention to in the storage process?

The peptide you received was packaged in lyophilized powder. Peptides are hydrophilic, and absorption of water will reduce the stability of the peptide and reduce the peptide content. Please pay attention to the following: first, with desiccants, stored in a dry environment. Second, once received, please immediately put into the freezer -20℃ storage, in order to maintain maximum stability. Third, avoid the use of no automatic frost function of the freezer. Changes in humidity and temperature can affect the stability of peptides. Fourth, the external temperature during transportation does not affect the validity and quality of peptides.

How is my peptide transported? What test reports are provided?

All freeze-dried polypeptides are usually stored in special containers of 2 ml or 10ml with original analytical data and synthesis reports containing important information such as sequence, molecular weight, purity, weight, and number of the polypeptide.

If a PT-141 is 98% pure, what is 2%?

Two percent of the composition was truncated or deleted sequence fragments.

Is it necessary to put a gap between the peptide and the dye?

If you are going to attach a large molecule (such as a dye) to the peptide, it is best to put a space between the peptide and the ligand to minimize interference with the receptor by the folding of the peptide itself or by the folding of its conjugate. Others do not want intervals. For example, in the folding of proteins, it is possible to determine how far apart the folding structure of an amino acid is by attaching a fluorescent dye to a particular site.